Cis-targeting has the potential to solve the most significant and challenging problem with immunotherapies: selectivity.
Immunotherapy is a significant breakthrough for the treatment of cancer and other diseases, but achieving the ideal level of precision remains a challenge, in part due to the inherent complexity of the immune system, which requires the coordinated action of many different cell types, as well as the abundant expression of immunotherapy targets across diverse cell types. Asher Bio is transforming the power of immunotherapy with new medicines designed to selectively activate only the immune cell types that promote a beneficial therapeutic effect, while simultaneously avoiding the opposing, antagonistic, and toxic effects driven by other immune cell types.
AB248 has demonstrated proof of mechanism and activity with a highly differentiated clinical profile in initial data from the ongoing Phase 1a/1b clinical trial. As a potential best-in-class IL-2, we are developing AB248 for the treatment of solid tumors. Beyond AB248, Asher Bio is applying our cis-targeting discovery platform to develop additional immunotherapies for the treatment of cancer and infectious disease.
Our leaders and scientific founders have deep expertise in immunotherapies and in building successful biotech companies. We are thriving and growing in the biotech hub of South San Francisco.
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