Our pioneering platform enables cis-targeted immunotherapies.

Cis-targeting has the potential to solve the most significant and challenging problem with immunotherapies: selectivity.

We are addressing a decades-old challenge of precision immune cell targeting.

Drug developers have tried to direct the immune system to treat disease, but have been unable to achieve the ideal level of precision. This is in part due to the inherent complexity of the immune system, which requires the coordinated action of many different cell types, as well as the abundant expression of immunotherapy targets across diverse cell types. Asher Bio is transforming the power of immunotherapy with new medicines designed to selectively activate only the immune cell types that promote a beneficial therapeutic effect, while simultaneously avoiding the opposing, antagonistic, and toxic effects driven by other immune cell types.

Our lead program is AB248, a cis-targeted IL-2 immunotherapy.

AB248 has shown superior anti-tumor activity in preclinical models compared to other IL-2 therapies currently available and in clinical development. As a potential best-in-class IL-2, we are developing AB248 for the treatment of solid tumors. Beyond AB248, Asher Bio is applying our cis-targeting discovery platform to develop additional immunotherapies for the treatment of cancer, autoimmune disease, and infectious disease.

Our team is experienced, entrepreneurial, and inspired.

Our leaders and scientific founders have deep expertise in immunotherapies and in building successful biotech companies. We are thriving and growing in the biotech hub of South San Francisco.

Management Team

Scientific Founders

Board of Directors

Ian Clark, Board Chair – Former CEO of Genentech
Bob Deresiewicz, MD – Former Partner and Portfolio Manager, Wellington Management Company, LLP
Ivana Djuretic, PhD – Founder, Chief Scientific Officer of Asher Bio
Craig Gibbs, PhD, MBA – Chief Executive Officer of Asher Bio
Reid Huber, PhD – Partner at Third Rock Ventures
Elaine Sun – Chief Operating Officer and Chief Financial Officer of Mammoth Biosciences, Inc. 
Jeffrey Tong, PhD – Partner at Third Rock Ventures

Scientific Advisory Board

George Georgiou, PhD – Professor and member of the faculties of Chemical Engineering, Molecular Biosciences, Biomedical Engineering as well as the Department of Oncology, Dell Medical School, University of Texas at Austin
Miriam Merad, MD, PhD – Director of the Precision Immunology Institute at Mount Sinai School of Medicine and Director of the Mount Sinai Human Immune Monitoring Center
Robert D. Schreiber, PhD – Bursky Distinguished Professor and Interim Head, Immunobiology Division, Department of Pathology and Immunology at Washington University School of Medicine; Director, Bursky Center for Human Immunology and Immunotherapy Programs
Ton Schumacher, PhD – Principal Investigator at The Netherlands Cancer Institute and Oncode Institute and Professor of Immunotechnology at Leiden University
Padmanee Sharma, MD, PhD – Professor, Departments of Immunology & GU Medical Oncology, MD Anderson Cancer Center
Mario Sznol, MD – Professor of Internal Medicine, Leader of the Melanoma-Renal Cancer Disease-Associated Translational Research Team, and Co-Leader of the Cancer Immunology Program at the Yale Cancer Center


Third Rock
Wellington Management
RA Capital
Janus Henderson Investors
Boxer Capital
Logos Capital
Mission Bay Capital
Y Combinator
Alexandria Venture Investments

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